Protocatechuic acid influences immune-metabolic changes in the adipose tissue of pregnant women with gestational diabetes mellitus

Author:

Scazzocchio Beatrice1,Filardi Tiziana2,Varì Rosaria1,Brunelli Roberto3,Galoppi Paola3ORCID,Morano Susanna2,Masella Roberta1,Santangelo Carmela1ORCID

Affiliation:

1. Center for Gender-Specific Medicine, Gender Specific Prevention and Health Unit, Istituto Superiore di Sanità, Viale Regina Elena, 299, 00161, Rome, Italy

2. Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy

3. Department of Maternal Childhood and Urological Sciences, Sapienza University, Rome, Italy

Abstract

Protocatechuic acid increased glucose uptake by p38MAPKinase activation, and rebalanced the inflammatory status by stimulating adiponectin release and reducing VPAC2 in adipose tissue explants from women with GDM.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

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