The design of experiments (DoE) in optimization of an aerobic flow Pd-catalyzed oxidation of alcohol towards an important aldehyde precursor in the synthesis of phosphatidylinositide 3-kinase inhibitor (CPL302415)-Reference-Cited by-同舟云学术

The design of experiments (DoE) in optimization of an aerobic flow Pd-catalyzed oxidation of alcohol towards an important aldehyde precursor in the synthesis of phosphatidylinositide 3-kinase inhibitor (CPL302415)

Published:2022 Issue:52 Volume:12 Page:33605-33611
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Michałek Stanisław¹²^ORCID,Gurba-Bryśkiewicz Lidia¹^ORCID,Maruszak Wioleta¹^ORCID,Zagozda Marcin¹,Maj Anna M.¹^ORCID,Ochal Zbigniew²,Dubiel Krzysztof¹,Wieczorek Maciej¹

Affiliation:

1. Celon Pharma S.A., Ul. Marymoncka 15, 05-152 Kazuń Nowy, Poland

2. Faculty of Chemistry, Warsaw University of Technology, Ul. Noakowskiego 3, 00-664 Warsaw, Poland

Abstract

DoE study of the aerobic flow Pd-catalyzed oxidation of an alcohol to an aldehyde in the synthesis of PI3Kδ inhibitor. The evaluation of green metrics show that the process is sustainable in comparison with two already known stoichiometric methods.

Funder

Narodowe Centrum Badań i Rozwoju

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/RA/D2RA07003K

Reference43 articles.

1. Design, Synthesis, and Biological Activity of Pyridopyrimidine Scaffolds as Novel PI3K/mTOR Dual Inhibitors

2. The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

3. The ubiquitous phosphoinositides