Sustainable methods for the carboxymethylation and methylation of ursolic acid with dimethyl carbonate under mild and acidic conditions-Reference-Cited by-同舟云学术

Sustainable methods for the carboxymethylation and methylation of ursolic acid with dimethyl carbonate under mild and acidic conditions

Published:2024 Issue:24 Volume:14 Page:16921-16934
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Kadsanit Nuttapong¹,Worsawat Pattamabhorn¹,Sakonsinsiri Chadamas²^ORCID,McElroy Con R.³⁴^ORCID,Macquarrie Duncan⁴^ORCID,Noppawan Pakin⁵^ORCID,Hunt Andrew J.¹^ORCID

Affiliation:

1. Materials Chemistry Research Center (MCRC), Department of Chemistry and Centre of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, 40002, Thailand

2. Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand

3. School of Chemistry, University of Lincoln, Brayford Pool Campus, Lincoln, LN6 7TS, UK

4. Green Chemistry Centre of Excellence, Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK

5. Department of Chemistry, Faculty of Science, Mahasarakham University, Maha Sarakham, 44150, Thailand

Abstract

Carboxymethylation and methylation of ursolic and corosolic acid have been achieved with dimethyl carbonate under sustainable, mild and acidic conditions. The resulting derivatives show potential as novel pharmaceutical intermediates.

Funder

Institute for the Promotion of Teaching Science and Technology

Materials Chemistry Research Center, Khon Kaen University

National Research Council of Thailand

Center of Excellence for Innovation in Chemistry

Ministry of Higher Education, Science, Research and Innovation, Thailand

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/RA/D4RA02122C

Reference111 articles.

1. Isolation of Ursolic Acid from Apple Peels and Its Specific Efficacy as a Potent Antitumor Agent

2. Oleanolic acid and ursolic acid induce apoptosis in four human liver cancer cell lines

3. Synthesis and evaluation as potential antitumor agents of novel ursolic acid derivatives

4. Ursolic acid derivatives induce cell cycle arrest and apoptosis in NTUB1 cells associated with reactive oxygen species