Exploring a new ligand binding site of G protein-coupled receptors-Reference-Cited by-同舟云学术

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Exploring a new ligand binding site of G protein-coupled receptors

Published:2018 Issue:31 Volume:9 Page:6480-6489
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Chan H. C. Stephen¹²³,Wang Jingjing⁴⁵⁶,Palczewski Krzysztof⁷⁸⁹,Filipek Slawomir¹⁰¹¹¹²¹³,Vogel Horst¹⁴¹⁵¹⁶,Liu Zhi-Jie⁴⁵⁶,Yuan Shuguang¹⁴¹⁵¹⁶^ORCID

Affiliation:

1. Faculty of Life Sciences

2. University of Bradford Bradford

3. UK

4. iHuman Institute

5. ShanghaiTech University

6. China

7. School of Medicine

8. Case Western Reserve University

9. USA

10. Faculty of Chemistry

11. Biological and Chemical Research Centre

12. University of Warsaw

13. Poland

14. Institute of Chemical Sciences and Engineering

15. Ecole Polytechnique Fédérale de Lausanne (EPFL)

16. Switzerland

Abstract

A new binding pocket of the endogenous ligand has been discovered by MD simulations.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/SC/C8SC01680A

Reference61 articles.

1. Implications of the small number of distinct ligand binding pockets in proteins for drug discovery, evolution and biochemical function

2. Drugging specific conformational states of GPCRs: challenges and opportunities for computational chemistry

3. Identification of Protein–Ligand Binding Sites by the Level-Set Variational Implicit-Solvent Approach

4. Protein Binding Pocket Dynamics

5. Implications of protein flexibility for drug discovery

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