Cooperativity as quantification and optimization paradigm for nuclear receptor modulators-Reference-Cited by-同舟云学术

Cooperativity as quantification and optimization paradigm for nuclear receptor modulators

Published:2022 Issue:9 Volume:13 Page:2744-2752
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

de Vink Pim J.¹^ORCID,Koops Auke A.¹^ORCID,D'Arrigo Giulia¹²^ORCID,Cruciani Gabriele³,Spyrakis Francesca²,Brunsveld Luc¹^ORCID

Affiliation:

1. Laboratory of Chemical Biology, Department of Biomedical Engineering and Institute for Complex Molecular Systems, Eindhoven University of Technology, P. O. Box 513, 5600MB Eindhoven, The Netherlands

2. Department of Drug Science and Technology, University of Turin, via Giuria 9, 10125 Turin, Italy

3. Department of Chemistry, Biology and Biotechnology, University of Perugia, Via Elce di Sotto 8, 06123, Perugia, Italy

Abstract

A cooperativity framework describes the formation of nuclear receptor ternary complexes and deconvolutes ligand and cofactor binding into intrinsic affinities and a cooperativity factor, providing a conceptually new understanding of NR modulation.

Funder

Nederlandse Organisatie voor Wetenschappelijk Onderzoek

Università degli Studi di Torino

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/SC/D1SC06426F

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1. Stabilization of protein-protein interactions in drug discovery

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