Targeting the Alternative Vitamin E Metabolite Binding Site Enables Noncanonical PPARγ Modulation-Reference-Cited by-同舟云学术

Targeting the Alternative Vitamin E Metabolite Binding Site Enables Noncanonical PPARγ Modulation

Published:2023-06-29 Issue:27 Volume:145 Page:14802-14810
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Arifi Silvia¹,Marschner Julian A.²,Pollinger Julius¹,Isigkeit Laura¹^ORCID,Heitel Pascal¹,Kaiser Astrid¹,Obeser Lennart²,Höfner Georg²,Proschak Ewgenij¹³^ORCID,Knapp Stefan¹⁴^ORCID,Chaikuad Apirat¹⁴^ORCID,Heering Jan³^ORCID,Merk Daniel¹²^ORCID

Affiliation:

1. Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, D-60438 Frankfurt, Germany

2. Department of Pharmacy, Ludwig-Maximilians-Universität München, D-81377 Munich, Germany

3. Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, D-60596 Frankfurt, Germany

4. Structural Genomics Consortium, BMLS, Goethe University Frankfurt, D-60438 Frankfurt, Germany

Funder

Innovative Medicines Initiative

H2020 European Research Council

Aventis Foundation

Fraunhofer Leistungszentrum innovative Therapeutics

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/jacs.3c03417

Reference43 articles.

1. International Union of Pharmacology. LXI. Peroxisome Proliferator-Activated Receptors

2. PPAR control of metabolism and cardiovascular functions

3. The safety of thiazolidinediones

4. Nonalcoholic steatohepatitis: the role of peroxisome proliferator-activated receptors

5. Targeting Nuclear Receptors in Neurodegeneration and Neuroinflammation

Cited by 13 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Tuning RXR Modulators for PGC1α Recruitment;Journal of Medicinal Chemistry;2024-09-11

2. Automated design of multi-target ligands by generative deep learning;Nature Communications;2024-09-11

3. Development of Tailless Homologue Receptor (TLX) Agonist Chemical Tools;Journal of Medicinal Chemistry;2024-09-05

4. Hydroxysafflor yellow A ameliorates alcohol-induced liver injury through PI3K/Akt and STAT3/NF-κB signaling pathways;Phytomedicine;2024-09

5. Nuclear Receptors and the Hidden Language of the Metabolome;Cells;2024-07-31