Cooperativity basis for small-molecule stabilization of protein–protein interactions-Reference-Cited by-同舟云学术

Cooperativity basis for small-molecule stabilization of protein–protein interactions

Published:2019 Issue:10 Volume:10 Page:2869-2874
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

de Vink Pim J.¹²³⁴⁵^ORCID,Andrei Sebastian A.¹²³⁴⁵^ORCID,Higuchi Yusuke⁶⁷⁸⁹^ORCID,Ottmann Christian¹²³⁴⁵^ORCID,Milroy Lech-Gustav¹²³⁴⁵^ORCID,Brunsveld Luc¹²³⁴⁵^ORCID

Affiliation:

1. Laboratory of Chemical Biology

2. Department of Biomedical Engineering and Institute for Complex Molecular Systems

3. Eindhoven University of Technology

4. Eindhoven

5. The Netherlands

6. The Institute of Scientific and Industrial Research

7. Osaka University

8. Ibaraki

9. Japan

Abstract

A cooperativity framework to describe and interpret small-molecule stabilization of protein–protein interactions (PPI) is presented, which allows elucidating structure–activity relationships regarding cooperativity and intrinsic affinity.

Funder

Nederlandse Organisatie voor Wetenschappelijk Onderzoek

Japan Society for the Promotion of Science

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/SC/C8SC05242E

Reference36 articles.

1. Modulators of Protein–Protein Interactions

2. Small-Molecule Inhibitors of Protein-Protein Interactions: Progressing toward the Reality