Synergistic Brønsted/Lewis acid catalyzed aromatic alkylation with unactivated tertiary alcohols or di-<i>tert</i>-butylperoxide to synthesize quaternary carbon centers-Reference-Cited by-同舟云学术

Synergistic Brønsted/Lewis acid catalyzed aromatic alkylation with unactivated tertiary alcohols or di-tert-butylperoxide to synthesize quaternary carbon centers

Published:2022 Issue:12 Volume:13 Page:3539-3548
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Pan Aaron¹^ORCID,Chojnacka Maja¹,Crowley Robert¹^ORCID,Göttemann Lucas¹,Haines Brandon E.²^ORCID,Kou Kevin G. M.¹^ORCID

Affiliation:

1. Department of Chemistry, University of California, Riverside, 501 Big Springs Road, Riverside, CA 92521, USA

2. Department of Chemistry, Westmont College, 955 La Paz Road, Santa Barbara, CA 93108, USA

Abstract

Dual Brønsted/Lewis acid catalysis involving environmentally benign, readily accessible protic acid and iron promotes site-selective tert-alkylation of arenes using di-tert-butylperoxide and tertiary alcohols.

Funder

National Science Foundation

University of California, Riverside

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/SC/D1SC06422C

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1. Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

2. The impact of aromatic ring count on compound developability – are too many aromatic rings a liability in drug design?