A ruthenium(ii) based photosensitizer and transferrin complexes enhance photo-physical properties, cell uptake, and photodynamic therapy safety and efficacy-Reference-Cited by-同舟云学术

A ruthenium(ii) based photosensitizer and transferrin complexes enhance photo-physical properties, cell uptake, and photodynamic therapy safety and efficacy

Published:2016 Issue:4 Volume:15 Page:481-495
ISSN:1474-905X
Container-title:Photochemical & Photobiological Sciences
language:en
Short-container-title:Photochem. Photobiol. Sci.

Author:

Kaspler Pavel¹²³,Lazic Savo¹²³,Forward Sarah⁴⁵⁶²³,Arenas Yaxal¹²³,Mandel Arkady¹²³,Lilge Lothar⁴⁵⁶²³

Affiliation:

1. Theralase Inc.

2. Toronto

3. Canada

4. University Health Network

5. Princess Margaret Cancer Research Tower and University of Toronto

6. Department of Medical Biophysics

Abstract

Mixing the novel Ru²⁺complex TLD1433 with transferrin prior to administration generates a photosensitizing drug with reduced dark toxicity and improved photophysical properties including NIR activation.

Publisher

Springer Science and Business Media LLC

Subject

Physical and Theoretical Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/PP/C5PP00450K

Reference78 articles.

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5. Studies of a vascular-acting photosensitizer, Pd-bacteriopheophorbide (Tookad), in normal canine prostate and spontaneous canine prostate cancer

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