Enantioselective bioreduction of benzo-fused cyclic ketones with engineered Candida glabrata ketoreductase 1 – a promising synthetic route to ladostigil (TV3326)

Author:

Ou-yang Jingping1234ORCID,Zhang Wenhe5634,Qin Fengyu5634,Zuo Weiguo1234,Xu Shaoyu1234,Wang Yan5634,Qin Bin7634,You Song5634,Jia Xian1234

Affiliation:

1. Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University)

2. Ministry of Education

3. Shenyang 110016

4. China

5. School of Life Sciences and Biopharmaceutical Sciences

6. Shenyang Pharmaceutical University

7. Wuya College of Innovation

Abstract

Engineered Candida glabrata ketoreductase 1 variants are applied to the bioreduction of benzo-fused cyclic ketones. Particularly, these biocatalysts showed excellent enantioselectivity towards a key intermediate of Ladostigil.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

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