Synthesis and Evaluation of (Pyridylmethylene)tetrahydronaphthalenes/-indanes and Structurally Modified Derivatives: Potent and Selective Inhibitors of Aldosterone Synthase-Reference-Cited by-同舟云学术

Synthesis and Evaluation of (Pyridylmethylene)tetrahydronaphthalenes/-indanes and Structurally Modified Derivatives: Potent and Selective Inhibitors of Aldosterone Synthase

Published:2005-02-10 Issue:5 Volume:48 Page:1563-1575
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Ulmschneider Sarah¹,Müller-Vieira Ursula¹,Klein Christian D.¹,Antes Iris¹,Lengauer Thomas¹,Hartmann Rolf W.¹

Affiliation:

1. FR 8.2 Pharmaceutical and Medicinal Chemistry, Saarland University, P.O. Box 15 11 50, D-66041 Saarbrücken, Germany, and Max Planck Institute for Informatics, Stuhlsatzenhausweg 85, D-66123 Saarbrücken, Germany

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm0492397

Reference57 articles.

1. Role of steroid 11 beta-hydroxylase and steroid 18-hydroxylase in the biosynthesis of glucocorticoids and mineralocorticoids in humans.

2. Renin–angiotensin–aldosterone system and myocardial fibrosis

3. Eplerenone, a Selective Aldosterone Blocker, in Patients with Left Ventricular Dysfunction after Myocardial Infarction

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