Affiliation:
1. Laboratory of Biocatalysis and Biotransformation Department of Drugs Technology and Biotechnology Faculty of Chemistry Warsaw University of Technology Koszykowa 75 00-662 Warsaw Poland
Abstract
AbstractThe reported chemoenzymatic strategy involves the employment of vinyl 3‐(dimethylamino)propanoate as an irreversible acyl donor in a chromatography‐free lipase‐catalyzed kinetic resolution (KR) of racemic sec‐alcohols. This biotransformation is achieved in a sequential manner using CAL‐B to affect the kinetic resolution, followed by a simple acidic extractive work‐up furnishing both KR products with excellent enantioselectivity (E>200; up to 98 % ee). The elaborated method eliminates a single‐use silica gel chromatographic separation and significantly reduces organic solvent consumption to foster a more environmentally friendly chemical industry.