Antihyperglycemic effect of an anthocyanin, cyanidin-3-<i>O</i>-glucoside, is achieved by regulating GLUT-1 <i>via</i> the Wnt/β-catenin-WISP1 signaling pathway-Reference-Cited by-同舟云学术

Antihyperglycemic effect of an anthocyanin, cyanidin-3-O-glucoside, is achieved by regulating GLUT-1 via the Wnt/β-catenin-WISP1 signaling pathway

Published:2022 Issue:8 Volume:13 Page:4612-4623
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Ye Xiang¹,Chen Wen¹^ORCID,Tu Pengcheng¹,Jia Ruoyi¹^ORCID,Liu Yangyang¹,Tang Qiong¹,Chen Chuan²,Yang Caihong³,Zheng Xiaodong¹,Chu Qiang⁴^ORCID

Affiliation:

1. Department of Food Science and Nutrition, Zhejiang Key Laboratory for Agro-food Processing, National Engineering Laboratory of Intelligent Food Technology and Equipment, Key Laboratory for Agro-Products Postharvest Handling of Ministry of Agriculture, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang University, Hangzhou 310058, China

2. Hangzhou Botanical Garden, Hangzhou, 310007, P. R. China

3. Hangzhou Qiandaohu Lingshanghuakai Agricultural Technology Co., Ltd, Hangzhou, 311701, P. R. China

4. Tea Research Institute, College of Agriculture & Biotechnology, Zhejiang University, Hangzhou, 310058, China

Abstract

We suggest that C3G promotes glucose uptake in liver cells by modulating the Wnt/β-catenin-WISP1 pathway to upregulate the expression of GLUT-1 associated with binding to β-catenin to enhance the signal transduction of the Wnt/β-catenin pathway.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2022/FO/D1FO03730G

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