Acid-responsive H2-releasing Fe nanoparticles for safe and effective cancer therapy

Author:

Kou Zhu12345ORCID,Zhao Penghe678910,Wang Zhihao12345,Jin Zhaokui678910,Chen Lihua12345ORCID,Su Bao-Lian11121314ORCID,He Qianjun678910ORCID

Affiliation:

1. Laboratory of Living Materials

2. The State Key Laboratory of Advanced Technology for Marterials Synthesis and Processing

3. Wuhan University of Technology

4. Wuhan

5. China

6. Guangdong Provincial Key Laboratory of Biomedical Measurements and Ultrasound Imaging

7. National-Regional Key Technology Engineering Laboratory for Medical Ultrasound

8. School of Biomedical Engineering

9. Health Science Center, Shenzhen University

10. Shenzhen 518060

11. Laboratory of Inorganic Marterials Chemistry (CMI)

12. University of Namur

13. B-5000 Namur

14. Belgium

Abstract

Hydrogen therapy is an emerging and promising strategy for the treatment of inflammation-related diseases owing to the excellent bio-safety of hydrogen molecules (H2), but is facing a challenge that the H2 concentration at the local disease site is hardly accumulated because of its high diffusibility and low solubility, limiting the efficacy of hydrogen therapy.

Funder

National Natural Science Foundation of China

Shenzhen University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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