Affiliation:
1. College of Biomedical Engineering Taiyuan University of Technology Taiyuan 030024 China
2. Departments of Diagnostic Radiology, Surgery Chemical and Biomolecular Engineering and Biomedical Engineering Yong Loo Lin School of Medicine and College of Design and Engineering National University of Singapore Singapore 119074 Singapore
3. Nanomedicine Translational Research Program NUS Center for Nanomedicine Yong Loo Lin School of Medicine National University of Singapore Singapore 117597 Singapore
4. Theranostics Center of Excellence (TCE) Yong Loo Lin School of Medicine National University of Singapore 11 Biopolis Way, Helios Singapore 138667 Singapore
5. Clinical Imaging Research Centre Centre for Translational Medicine Yong Loo Lin School of Medicine National University of Singapore Singapore 117599 Singapore
Abstract
AbstractHydrogen (H2) therapy is an emerging, novel, and safe therapeutic modality that uses molecular hydrogen for effective treatment. However, the impact of H2 therapy is limited because hydrogen molecules predominantly depend on the systemic administration of H2 gas, which cannot accumulate at the lesion site with high concentration, thus leading to limited targeting and utilization. Biomaterials are developed to specifically deliver H2 and control its release. In this review, the development process, stimuli‐responsive release strategies, and potential therapeutic mechanisms of biomaterial‐based H2 therapy are summarized. H2 therapy. Specifically, the produced H2 from biomaterials not only can scavenge free radicals, such as reactive oxygen species (ROS) and lipid peroxidation (LPO), but also can inhibit the danger factors of initiating diseases, including pro‐inflammatory cytokines, adenosine triphosphate (ATP), and heat shock protein (HSP). In addition, the released H2 can further act as signal molecules to regulate key pathways for disease treatment. The current opportunities and challenges of H2‐based therapy are discussed, and the future research directions of biomaterial‐based H2 therapy for clinical applications are emphasized.
Funder
National Natural Science Foundation of China