Intratumoral H2O2-triggered release of CO from a metal carbonyl-based nanomedicine for efficient CO therapy-Reference-Cited by-同舟云学术

Intratumoral H2O2-triggered release of CO from a metal carbonyl-based nanomedicine for efficient CO therapy

Published:2017 Issue:40 Volume:53 Page:5557-5560
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Jin Zhaokui¹²³⁴⁵,Wen Yanyuan¹²³⁴⁵,Xiong Liwei⁶⁷⁸⁹,Yang Tian¹²³⁴⁵,Zhao Penghe¹²³⁴⁵,Tan Liwei¹⁰¹¹¹²¹³¹⁴,Wang Tianfu¹²³⁴⁵,Qian Zhiyong¹⁰¹¹¹²¹³¹⁴^ORCID,Su Bao-Lian¹⁵¹⁶¹⁷¹⁸,He Qianjun¹²³⁴⁵^ORCID

Affiliation:

1. National-Regional Key Technology Engineering Laboratory for Medical Ultrasound

2. Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging

3. School of Biomedical Engineering

4. Health Science Center

5. Shenzhen University

6. Hubei Key Laboratory of Plasma Chemistry and Advanced Materials

7. Wuhan Institute of Technology

8. Wuhan

9. China

10. State Key Laboratory of Biotherapy and Cancer Centre

11. Collaborative Innovation Centre for Biotherapy

12. West China Hospital

13. Sichuan University

14. Chengdu 610041

15. State Key Laboratory of Advanced Technology for Materials Synthesis and Processing

16. Wuhan University of Technology

17. Wuhan 430070

18. P. R. China

Abstract

H₂O₂-triggered release of CO: an intratumoral H₂O₂-responsive nanomedicine is constructed by effectively encapsulating the hydrophilic manganese carbonyl prodrug into an advanced hollow mesoporous silica nanoparticle carrier to realize selective killing of tumor cells, exhibiting high in vitro and in vivo efficacies of CO gas therapy.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2017/CC/C7CC01576C

Reference21 articles.

1. Stimuli-responsive nanocarriers for drug delivery

2. Development of individualized anti-metastasis strategies by engineering nanomedicines

3. Biodegradable luminescent porous silicon nanoparticles for in vivo applications

4. The therapeutic potential of carbon monoxide

5. X-ray Radiation-Controlled NO-Release for On-Demand Depth-Independent Hypoxic Radiosensitization

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