Process analytical technology (PAT): applications to flow processes for active pharmaceutical ingredient (API) development

Author:

Talicska Courtney N.1ORCID,O'Connell Eamon C.1,Ward Howard W.1,Diaz Angel R.1,Hardink Mark A.1,Foley David A.12ORCID,Connolly Douglas3,Girard Kevin P.1ORCID,Ljubicic Tomislav1

Affiliation:

1. Analytical Research and Development, Pfizer Worldwide Research and Development, 445 Eastern Point Road, Groton, Connecticut 06340, USA

2. Employed at Pfizer during the time of this work, now at Merck Research and Development, 90 E Scott Ave, Rahway, New Jersey 07065, USA

3. Contingent Worker, Eurofins Scientific for Pfizer Worldwide Research and Development, 445 Eastern Point Rd, Groton, Connecticut, 06340, USA

Abstract

Process analytical technology (PAT) applications pertaining to Pfizer's Flexible API Supply Technology (FAST) initiative.

Publisher

Royal Society of Chemistry (RSC)

Subject

Fluid Flow and Transfer Processes,Process Chemistry and Technology,Chemical Engineering (miscellaneous),Chemistry (miscellaneous),Catalysis

Reference40 articles.

1. Chemical Engineering in the Pharmaceutical Industry: Active Pharmaceutical Ingredients , ed. D. J. A. Ende and M. T. A. Ende , John Wiley & Sons , 2nd edn, 2019

2. Laboratory of the future: a modular flow platform with multiple integrated PAT tools for multistep reactions

3. Advanced Real‐Time Process Analytics for Multistep Synthesis in Continuous Flow**

4. Industry Perspectives on Process Analytical Technology: Tools and Applications in API Development

5. Process Analytical Technology: Spectroscopic Tools and Implementation Strategies for the Chemical and Pharmaceutical Industries , ed. K. A. Bakeev , John Wiley & Sons , West Sussex, U.K. , 2nd edn, 2010

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