Synergistic activity of a short lipidated antimicrobial peptide (lipoAMP) and colistin or tobramycin against Pseudomonas aeruginosa from cystic fibrosis patients

Author:

de Gier Martin G.12345,Bauke Albada H.678910,Josten Michaele111213149,Willems Rob152345,Leavis Helen152345,van Mansveld Rosa152345,Paganelli Fernanda L.152345,Dekker Bertie152345,Lammers Jan-Willem J.12345,Sahl Hans-Georg111213149,Metzler-Nolte Nils6789ORCID

Affiliation:

1. Department of Pulmonology

2. University Medical Center Utrecht

3. University of Utrecht

4. Utrecht

5. The Netherlands

6. Inorganic Chemistry I – Bioinorganic Chemistry

7. Ruhr University Bochum

8. Bochum

9. Germany

10. The Center for Nanoscience and Nanotechnology

11. Institute of Medical Microbiology, Immunology, and Parasitology

12. Pharmaceutical Microbiology Section

13. University of Bonn

14. Bonn

15. Department of Medical Microbiology

Abstract

Synergistic effects between a lipoAMP and colistin against clinical P. aeruginosa strains isolated from cystic fibrosis patients are described.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

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