Synergistic Activity of Repurposed Peptide Drug Glatiramer Acetate with Tobramycin against Cystic Fibrosis Pseudomonas aeruginosa-Reference-Cited by-同舟云学术

Synergistic Activity of Repurposed Peptide Drug Glatiramer Acetate with Tobramycin against Cystic Fibrosis Pseudomonas aeruginosa

Published:2022-08-31 Issue:4 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Murphy Ronan A.¹^ORCID,Coates Matthew¹,Thrane Sophia²,Sabnis Akshay³,Harrison James⁴,Schelenz Silke⁵,Edwards Andrew M.³^ORCID,Vorup-Jensen Thomas²,Davies Jane C.¹⁶

Affiliation:

1. National Heart and Lung Institute, Imperial College London, London, United Kingdom

2. Department of Biomedicine, Aarhus University, Aarhus, Denmark

3. MRC Centre for Molecular Bacteriology and Infection, Imperial College London, London, United Kingdom

4. Cycle Pharmaceutical Ltd., Cambridge, United Kingdom

5. King’s College Hospital NHS Foundation Trust, KingsPath Clinical Diagnostics Pathology Services, London, United Kingdom

6. Department of Paediatric Respiratory Medicine, Royal Brompton Hospital, London, United Kingdom

Abstract

The antimicrobial resistance crisis urgently requires solutions to the lost efficacy of antibiotics. The repurposing of drugs already in clinical use, with strong safety profiles, as antibiotic adjuvants to restore the efficacy of antibiotics is an important avenue to alleviating the resistance crisis.

Funder

Cystic Fibrosis Trust

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.00813-22

Reference75 articles.

1. Charman S McClenaghan E Cosgriff R Lee A Carr S. 2019. UK Cystic Fibrosis Registry annual data report 2018. Cystic Fibrosis Trust London United Kingdom.

2. Origins of Cystic Fibrosis Lung Disease

3. Cystic fibrosis

4. Cystic fibrosis

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