Interplay of nucleophilic catalysis with proton transfer in the nitrile reductase QueF from Escherichia coli-Reference-Cited by-同舟云学术

Interplay of nucleophilic catalysis with proton transfer in the nitrile reductase QueF from Escherichia coli

Published:2019 Issue:3 Volume:9 Page:842-853
ISSN:2044-4753
Container-title:Catalysis Science & Technology
language:en
Short-container-title:Catal. Sci. Technol.

Author:

Jung Jihye¹²³⁴⁵,Braun Jan¹²³⁴⁵,Czabany Tibor¹²³⁴⁵,Nidetzky Bernd¹²³⁴⁵^ORCID

Affiliation:

1. Institute of Biotechnology and Biochemical Engineering

2. Graz University of Technology

3. NAWI Graz

4. A-8010 Graz

5. Austria

Abstract

Proton relay through an active-site network of hydrogen bonds promotes enzymatic nitrile reduction to amine via a covalent thioimidate enzyme intermediate.

Funder

Bundesministerium für Verkehr, Innovation und Technologie

Steirische Wirtschaftsförderungsgesellschaft

Standortagentur Tirol

Österreichische Forschungsförderungsgesellschaft

Publisher

Royal Society of Chemistry (RSC)

Subject

Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2019/CY/C8CY02331J

Reference48 articles.

1. A conserved mechanism for nitrile metabolism in bacteria and plants

2. Nitrilase enzymes and their role in plant-microbe interactions

3. Exploring anaerobic environments for cyanide and cyano-derivatives microbial degradation

4. Nitrile-converting enzymes: An eco-friendly tool for industrial biocatalysis

5. Nitrile-converting enzymes as a tool to improve biocatalysis in organic synthesis: recent insights and promises

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