Towards solvent regulated self-activation of N-terminal disulfide bond oxidoreductase-D-Reference-Cited by-同舟云学术

Towards solvent regulated self-activation of N-terminal disulfide bond oxidoreductase-D

Published:2022 Issue:13 Volume:24 Page:7691-7699
ISSN:1463-9076
Container-title:Physical Chemistry Chemical Physics
language:en
Short-container-title:Phys. Chem. Chem. Phys.

Author:

Nair Aparna G¹,Perumalla D. Sravanakumar¹^ORCID,Anjukandi Padmesh¹^ORCID

Affiliation:

1. Department of Chemistry, Indian Institute of Technology, Palakkad-678557, Kerala, India

Abstract

An alternative mechanism for disulfide bond cleavage in nDsbDOxvia an internal nucleophile (Tyr42O−) and its stabilization through water network is investigated and captured.

Funder

Science and Engineering Research Board

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CP/D1CP05819C

Reference84 articles.

1. Multifaceted Roles of Disulfide Bonds. Peptides as Therapeutics

2. Oxidative stress, protein damage and repair in bacteria

3. Allosteric Disulfide Bonds

4. Chemistry and Enzymology of Disulfide Cross-Linking in Proteins

5. Targeting virulence for antimicrobial chemotherapy

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