Molecular detection using aptamer-modified gold nanoparticles with an immobilized DNA brush for the prevention of non-specific aggregation

Author:

Yano-Ozawa Yuki12345,Lobsiger Nadine12345,Muto Yu12345,Mori Takahiro12345,Yoshimura Ken12345,Yano Yuki12345,Stark Wendelin Jan6789ORCID,Maeda Mizuo1011125,Asahi Tsuyoshi12345,Ogawa Atsushi13345ORCID,Zako Tamotsu12345ORCID

Affiliation:

1. Department of Chemistry and Biology

2. Graduate School of Science and Engineering

3. Ehime University

4. Matsuyama

5. Japan

6. Institute for Chemical and Bioengineering

7. ETH Zürich

8. CH-8093 Zürich

9. Switzerland

10. Bioengineering Laboratory

11. RIKEN Cluster for Pioneering Research

12. Wako

13. Proteo-Science Center

Abstract

We demonstrated molecular detection using aptamer-modified gold nanoparticles with DNA-brush for the prevention of non-specific aggregation and smartphone darkfield microscopy.

Funder

Japan Society for the Promotion of Science

Ehime University

Eidgenössische Technische Hochschule Zürich

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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