Species differences in drug plasma protein binding-Reference-Cited by-同舟云学术

Species differences in drug plasma protein binding

Published:2014 Issue:7 Volume:5 Page:963-967
ISSN:2040-2503
Container-title:Med. Chem. Commun.
language:en
Short-container-title:Med. Chem. Commun.

Author:

Colclough Nicola¹²,Ruston Linette¹²,Wood J. Matthew¹²,MacFaul Philip A.¹²

Affiliation:

1. AstraZeneca

2. Macclesfield, UK

Abstract

Comparison of the human plasma protein binding data for a variety of drug discovery compounds indicates that compounds tend to be slightly more bound to human plasma proteins, than compared to plasma proteins from rats, dogs or mice.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/MD/C4MD00148F

Reference22 articles.

1. W. A. Creasey , Drug Disposition in Humans: The Basis of Clinical Pharmacology , Oxford Univeristy Press , Oxford, U.K. , 1979

2. The importance of plasma protein binding in drug discovery

3. Plasma protein binding: From discovery to development

4. The effect of plasma protein binding on in vivo efficacy: misconceptions in drug discovery

5. When is Protein Binding Important?*

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