Optimized J to T peak and T peak to T end measurements in nonclinical species administered moxifloxacin and amiodarone

Author:

Bartko Theresa M.,Lutgen Stephen M.,Ross Rebecca A.,Walisser Jacqueline A.,Garske Eric P.,Kopelke Kerry R.,Ashcroft-Hawley Kelly,Tang Hai-Ming,Kremer John J.,Friedrichs Gregory S.,Nichols Jill V.

Funder

Novartis Pharmaceuticals Corporation

Publisher

Elsevier BV

Reference29 articles.

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2. Heart rate corrected JTp and TpTe as proarrhythmia biomarkers in safety pharmacology non-human primate studies: Outcome from a HESI consortium prospective study;Authier,2023

3. JTpeak assessment in ambulatory dog and monkey an update from the HESI working group;Authier,2022

4. Disposition of amiodarone and its proximate metabolite, desethylamiodarone, in the dog for oral administration of single-dose and short-term drug regimens;Brien;Drug Metabolism and Disposition,1990

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1. Innovative approaches to cardiovascular safety pharmacology assessment;Journal of Pharmacological and Toxicological Methods;2024-07

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