Optimization of Ethoxzolamide Analogs with Improved Pharmacokinetic Properties for <i>In Vivo</i> Efficacy against <i>Neisseria gonorrhoeae</i>-Reference-Cited by-同舟云学术

Optimization of Ethoxzolamide Analogs with Improved Pharmacokinetic Properties for In Vivo Efficacy against Neisseria gonorrhoeae

Published:2024-08-14 Issue:17 Volume:67 Page:15537-15556
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Youse Molly S.¹,Abutaleb Nader S.²³,Nocentini Alessio⁴^ORCID,S Abdelsattar Abdallah²³,Ali Farman¹,Supuran Claudiu T.⁴^ORCID,Seleem Mohamed N.²³^ORCID,Flaherty Daniel P.¹⁵⁶^ORCID

Affiliation:

1. Borch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, Indiana 47907, United States

2. Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, United States

3. Center for One Health Research, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, United States

4. Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Polo Scientifico, Firenze 50122, Italy

5. Purdue Institute for Drug Discovery, West Lafayette, Indiana 47907, United States

6. Purdue Institute of Inflammation, Immunology and Infectious Disease, West Lafayette, Indiana 47907, United States

Funder

Ministero dell???Istruzione, dell???Universit?? e della Ricerca

U.S. Department of Health and Human Services

European Commission

Purdue Institute for Drug Discovery

Purdue College of Pharmacy

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c01187

Reference127 articles.

1. Multi-Drug Resistant Gonorrhoea. World Health Organization. https://www.who.int/news-room/fact-sheets/detail/multi-drug-resistant-gonorrhoea (accessed 2022–07–01).

2. Antibacterial activity of resazurin-based compounds against Neisseria gonorrhoeae in vitro and in vivo

3. Gonorrhoea

4. Disseminated gonococcal infection (DGI) and gonococcal arthritis (GCA): II. Clinical manifestations, diagnosis, complications, treatment, and prevention

5. Centers for Disease Control and Prevention. Sexually Transmitted Infections Surveillance 2022. U.S. Department of Health and Human Services. https://www.cdc.gov/std/statistics/2022/default.htm.