Site-specific bioalkylation of rapamycin by the RapM 16-O-methyltransferase-Reference-Cited by-同舟云学术

Site-specific bioalkylation of rapamycin by the RapM 16-O-methyltransferase

Published:2015 Issue:5 Volume:6 Page:2885-2892
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Law Brian J. C.¹²³⁴,Struck Anna-Winona¹²³⁴,Bennett Matthew R.¹²³⁴,Wilkinson Barrie⁵⁶⁷⁴⁸,Micklefield Jason¹²³⁴

Affiliation:

1. School of Chemistry and Manchester Institute of Biotechnology

2. The University of Manchester

3. Manchester

4. UK

5. Department of Molecular Microbiology

6. John Innes Centre

7. Norwich

8. Isomerase Therapeutics Ltd

Abstract

Characterisation of a rapamycin O-methyltransferase (RapM) and its utilisation in coupled reactions, with an improved variant of the human methionine adenosyl transferase (hMAT2A), results in new regioselectively alkylated rapamycin derivatives.

Funder

Biotechnology and Biological Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/SC/C5SC00164A

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