An efficient heterogenized palladium catalyst for N-alkylation of amines and α-alkylation of ketones using alcohols

Author:

Dang Tuan Thanh123,Shan Siah Pei123,Ramalingam Balamurugan123,Seayad Abdul Majeed123

Affiliation:

1. Organic Chemistry

2. Institute of Chemical and Engineering Sciences (ICES)

3. Singapore 138665

Abstract

Silica supported palladium–NiXantphos complex is an efficient and high turnover heterogeneous catalyst for N-alkylation of amines and α-alkylation of ketones using alcohols under neat conditions at 120–140 °C following hydrogen borrowing strategy.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Reference161 articles.

1. A. de Meijere and F.Diederich, in Metal-Catalyzed Cross-Coupling Reactions, Wiley-VCH, Weinheim, 2004

2. Modern amination methods, ed. A. Ricci, Wiley-VCH, Weinheim, 2000

3. A. R. Cartolano and G. A.Vedage, in Kirk-Othmer Encyclopedia of Chemical Technology, John Wiley & Sons, Inc, New York, 2004, vol. 2, pp. 476–498

4. Amino Group Chemistry: From Synthesis to the Life Sciences, ed. A. Ricci, Wiley-VCH, Weinheim, 2008

5. Amines: Synthesis, Properties, and Applications, ed. S. A. Lawrence, Cambridge University, Cambridge, 2006

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