Synthesis of 3-aryl-3-benzazepines via aryne [1,2] Stevens rearrangement of 1,2,3,4-tetrahydroisoquinolines-Reference-Cited by-同舟云学术

Synthesis of 3-aryl-3-benzazepines via aryne [1,2] Stevens rearrangement of 1,2,3,4-tetrahydroisoquinolines

Published:2018 Issue:11 Volume:5 Page:1798-1810
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Pan Xuan¹²³⁴⁵,Liu Zhanzhu¹²³⁴⁵^ORCID

Affiliation:

1. State Key Laboratory of Bioactive Substances and Functions of Natural Medicines

2. Institute of Materia Medica

3. Peking Union Medical College and Chinese Academy of Medical Sciences

4. Beijing 100050

5. P. R. China

Abstract

An efficient method for the synthesis of 3-aryl-3-benzazepines via aryne induced [1,2] Stevens rearrangement of 1,2,3,4-tetrahydroisoquinolines is described.

Funder

Chinese Academy of Medical Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/QO/C8QO00275D

Reference31 articles.

1. 1,2,4-Triazol-3-yl-thiopropyl-tetrahydrobenzazepines: A Series of Potent and Selective Dopamine D3 Receptor Antagonists

2. Remote functionalization of SCH 39166: Discovery of potent and selective benzazepine dopamine D1 receptor antagonists

3. Discovery and SAR of new benzazepines as potent and selective 5-HT2C receptor agonists for the treatment of obesity

4. A new facile synthetic route to [11C]GSK189254, a selective PET radioligand for imaging of CNS histamine H3 receptor

5. Norpiperidine Imidazoazepines as a New Class of Potent, Selective, and Nonsedative H1 Antihistamines

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