Discovery and SAR of new benzazepines as potent and selective 5-HT2C receptor agonists for the treatment of obesity-Reference-Cited by-同舟云学术

Discovery and SAR of new benzazepines as potent and selective 5-HT2C receptor agonists for the treatment of obesity

Published:2005-03 Issue:5 Volume:15 Page:1467-1470
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Smith Brian M.,Smith Jeffrey M.,Tsai James H.,Schultz Jeffrey A.,Gilson Charles A.,Estrada Scott A.,Chen Rita R.,Park Douglas M.,Prieto Emily B.,Gallardo Charlemagne S.,Sengupta Dipanjan,Thomsen William J.,Saldana Hazel R.,Whelan Kevin T.,Menzaghi Frederique,Webb Robert R.,Beeley Nigel R.A.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference16 articles.

1. 5-HT2C Receptor Agonists as Potential Drugs for the Treatment of Obesity

2. 5-HT 2C receptor activation decreases appetite and body weight in obese subjects

3. Oral administration of the 5-HT2C receptor agonist, mCPP, reduces body weight gain in rats over 28 days as a result of maintained hypophagia

4. Evidence that hypophagia induced by d-fenfluramine and d-norfenfluramine in the rat is mediated by 5-HT2C receptors

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