Site-specific recognition of SARS-CoV-2 nsp1 protein with a tailored titanium dioxide nanoparticle – elucidation of the complex structure using NMR data and theoretical calculation-Reference-Cited by-同舟云学术

Site-specific recognition of SARS-CoV-2 nsp1 protein with a tailored titanium dioxide nanoparticle – elucidation of the complex structure using NMR data and theoretical calculation

Published:2022 Issue:6 Volume:4 Page:1527-1532
ISSN:2516-0230
Container-title:Nanoscale Advances
language:en
Short-container-title:Nanoscale Adv.

Author:

Agback Peter¹,Agback Tatiana¹^ORCID,Dominguez Francisco²,Frolova Elena I.²,Seisenbaeva Gulaim A.¹^ORCID,Kessler Vadim G.¹^ORCID

Affiliation:

1. Department of Molecular Sciences, Swedish University of Agricultural Sciences, Box 7015, SE-75007, Uppsala, Sweden

2. Department of Microbiology, University of Alabama at Birmingham, 1720 2nd Ave South Birmingham, AL 35294, USA

Abstract

Titanium dioxide nanoparticles can be tailored to interact specifically with SARS-CoV-2 nsp1 protein, forming, according to NMR studies, a stable complex, which structure was elucidated based on a molecular modeling approach.

Funder

Vetenskapsrådet

Stiftelsen för Strategisk Forskning

Publisher

Royal Society of Chemistry (RSC)

Subject

General Engineering,General Materials Science,General Chemistry,Atomic and Molecular Physics, and Optics,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2022/NA/D1NA00855B

Reference46 articles.

1. Coronavirus biology and replication: implications for SARS-CoV-2

2. Continuous and Discontinuous RNA Synthesis in Coronaviruses