Kinetic analysis of sequential metabolism of triazolam and its extrapolation to humans using an entero-hepatic two-organ microphysiological system-Reference-Cited by-同舟云学术

Kinetic analysis of sequential metabolism of triazolam and its extrapolation to humans using an entero-hepatic two-organ microphysiological system

Published:2020 Issue:3 Volume:20 Page:537-547
ISSN:1473-0197
Container-title:Lab on a Chip
language:en
Short-container-title:Lab Chip

Author:

Arakawa Hiroshi¹²³⁴⁵^ORCID,Sugiura Shinji⁶⁷⁸⁵^ORCID,Kawanishi Takumi¹²³⁴⁵,Shin Kazumi⁶⁷⁸⁵,Toyoda Hiroko⁶⁷⁸⁵⁹,Satoh Taku⁶⁷⁸⁵⁹,Sakai Yasuyuki¹⁰¹¹¹²⁵,Kanamori Toshiyuki⁶⁷⁸⁵,Kato Yukio¹²³⁴⁵^ORCID

Affiliation:

1. Faculty of Pharmacy

2. Institute of Medical, Pharmaceutical and Health Sciences

3. Kanazawa University

4. Kanazawa

5. Japan

6. Biotechnology Research Institute for Drug Discovery

7. National Institute of Advanced Industrial Science and Technology (AIST)

8. Tsukuba

9. Stem Cell Evaluation Technology Research Association

10. Department of Chemical System Engineering

11. Graduate School of Engineering

12. The University of Tokyo

Abstract

We have constructed a mechanism-based pharmacokinetic model for triazolam and its metabolites in the entero-hepatic two-organ MPS, and extrapolated the kinetic information obtained with the MPS to the plasma concentration profiles in humans.

Funder

Japan Agency for Medical Research and Development

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2020/LC/C9LC00884E

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