Perfluoropolyether-Based Gut-Liver-on-a-Chip for the Evaluation of First-Pass Metabolism and Oral Bioavailability of Drugs-Reference-Cited by-同舟云学术

Perfluoropolyether-Based Gut-Liver-on-a-Chip for the Evaluation of First-Pass Metabolism and Oral Bioavailability of Drugs

Published:2024-06-01 Issue:7 Volume:10 Page:4635-4644
ISSN:2373-9878
Container-title:ACS Biomaterials Science & Engineering
language:en
Short-container-title:ACS Biomater. Sci. Eng.

Author:

Wang Mengyang¹,Sasaki Yuko²,Sakagami Rena¹,Minamikawa Tomotaka²,Tsuda Masahiro²,Ueno Ryohei³,Deguchi Sayaka⁴,Negoro Ryosuke⁵,So Kanako²,Higuchi Yuriko¹,Yokokawa Ryuji³^ORCID,Takayama Kazuo⁴^ORCID,Yamashita Fumiyoshi¹²^ORCID

Affiliation:

1. Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan

2. Department of Applied Pharmaceutics and Pharmacokinetics, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan

3. Department of Micro Engineering, Graduate School of Engineering, Kyoto University, Kyoto 615-8540, Japan

4. Center for iPS Cell Research and Application, Kyoto University, Kyoto 606-8507, Japan

5. Laboratory of Molecular Pharmacokinetics, College of Pharmaceutical Sciences, Ritsumeikan University, Shiga 525-8577, Japan

Funder

Japan Agency for Medical Research and Development

Japan Society for the Promotion of Science

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acsbiomaterials.4c00605

Reference65 articles.

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3. Interplay of Metabolism and Transport in Determining Oral Drug Absorption and Gut Wall Metabolism: A Simulation Assessment Using the “Advanced Dissolution, Absorption, Metabolism (ADAM)” Model

4. Advances in computationally modeling human oral bioavailability

5. Intestinal Permeability and Drug Absorption: Predictive Experimental, Computational and In Vivo Approaches