Metabolic perturbations and health impact from exposure to a combination of multiple harmful Maillard reaction products on Sprague-Dawley rats

Author:

Quan Wei12ORCID,Lin Yong3,Xue Chaoyi2,Cheng Yong2,Luo Jie1,Lou Aihua1,Zeng Maomao2ORCID,He Zhiyong2ORCID,Shen Qingwu1,Chen Jie24ORCID

Affiliation:

1. College of Food Science and Technology, Hunan Agricultural University, Changsha, Hunan 410128, China

2. State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China

3. National Research Center of Engineering Technology for Utilization of Functional Ingredients from Botanicals, Hunan Agricultural University, Changsha, Hunan 410128, China

4. International Joint Laboratory on Food Safety, Jiangnan University, Wuxi, Jiangsu 214122, China

Abstract

The metabolic perturbations and health impact of the co-accumulation of acrylamide, harmane, and Nε-(carboxymethyl)lysine was investigated via serum biochemical and histopathological examinations as well as metabolomic analysis.

Funder

Jiangnan University

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

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