The syntheses of α-ketoamides vianBu4NI-catalyzed multiple sp3C–H bond oxidation of ethylarenes and sequential coupling with dialkylformamides-Reference-Cited by-同舟云学术

The syntheses of α-ketoamides vianBu4NI-catalyzed multiple sp3C–H bond oxidation of ethylarenes and sequential coupling with dialkylformamides

Published:2014 Issue:26 Volume:12 Page:4586-4589
ISSN:1477-0520
Container-title:Org. Biomol. Chem.
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Du Bingnan¹²³⁴,Jin Bo¹²³⁴,Sun Peipei¹²³⁴⁵

Affiliation:

1. Jiangsu Key Laboratory of Biofunctional Materials

2. College of Chemistry and Materials Science

3. Nanjing Normal University

4. Nanjing 210097, China

5. Jiangsu Collaborative Innovation Center of Biomedical Functional Materials

Abstract

The ⁿBu₄NI-catalyzed sequential C–O and C–N bond formation via multiple sp³C–H bond activation of ethylarenes, using N,N-dialkylformamide as the amino source, provided α-ketoamides with moderate yields.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/OB/C4OB00520A

Reference53 articles.

1. Molecular Recognition of Protein−Ligand Complexes: Applications to Drug Design

2. Peptide .alpha.-keto ester, .alpha.-keto amide, and .alpha.-keto acid inhibitors of calpains and other cysteine proteases

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4. Synthesis and activity studies of conformationally restricted α-ketoamide factor Xa inhibitors

5. Probing Immunosuppressant Action with a Nonnatural Immunophilin Ligand

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