Large ring-forming alkylations provide facile access to composite macrocycles
Author:
Affiliation:
1. Department of Chemistry and Biochemistry
2. University of California Los Angeles
3. Los Angeles
4. USA
Abstract
Friedel–Crafts cinnamylations can form unique and varied macrocycles with unmatched ease and functional group tolerance.
Funder
Division of Graduate Education
Division of Chemistry
National Cancer Institute
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2015/SC/C4SC03848G
Reference40 articles.
1. The exploration of macrocycles for drug discovery — an underexploited structural class
2. Getting in Shape: Controlling Peptide Bioactivity and Bioavailability Using Conformational Constraints
3. Macrocycles Are Great Cycles: Applications, Opportunities, and Challenges of Synthetic Macrocycles in Drug Discovery
4. On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds
5. Optimizing PK properties of cyclic peptides: the effect of side chain substitutions on permeability and clearance
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