C(sp2)–H cyclobutylation of hydroxyarenes enabled by silver-π-acid catalysis: diastereocontrolled synthesis of 1,3-difunctionalized cyclobutanes

Author:

Tang Lei1ORCID,Huang Qi-Nan1ORCID,Wu Feng1ORCID,Xiao Yuanjiu1ORCID,Zhou Jin-Lan1ORCID,Xu Tong-Tong1ORCID,Wu Wen-Biao1ORCID,Qu Shuanglin1ORCID,Feng Jian-Jun1ORCID

Affiliation:

1. State Key Laboratory of Chemo/Biosensing and Chemometrics, Advanced Catalytic Engineering Research Center of the Ministry of Education, College of Chemistry and Chemical Engineering, Hunan University, Changsha, Hunan 410082, P. R. China

Abstract

A carbophilic silver Lewis acid catalyzes polar strain-release ring-opening of BCBs with hydroxyarenes to afford 1,1,3-trisubstituted cyclobutanes in high yields and excellent chemo- and diastereoselectivity.

Funder

Fundamental Research Funds for the Central Universities

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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