Diastereoselective Synthesis of a cis-1,3-Disubstituted Cyclobutane Carboxylic Acid Scaffold for TAK-828F, a Potent Retinoic Acid Receptor-Related Orphan Receptor (ROR)-γt Inverse Agonist
Author:
Affiliation:
1. Process Chemistry, Pharmaceutical Sciences, Takeda Pharmaceutical Company Limited, 17-85 Jusohonmachi 2-Chome, Yodogawa-ku, Osaka 532-8686, Japan
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.joc.1c00970
Reference39 articles.
1. (Inverse) Agonists of Retinoic Acid–Related Orphan Receptor γ: Regulation of Immune Responses, Inflammation, and Autoimmune Disease
2. Retinoid-Related Orphan Receptors (RORs): Critical Roles in Development, Immunity, Circadian Rhythm, and Cellular Metabolism
3. Modulators of the Nuclear Receptor Retinoic Acid Receptor-Related Orphan Receptor-γ (RORγ or RORc)
4. Recent progress on nuclear receptor RORγ modulators
5. Combating Autoimmune Diseases With Retinoic Acid Receptor-Related Orphan Receptor-γ (RORγ or RORc) Inhibitors: Hits and Misses
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1. Functionalized Alkylidenecyclobutanes from a Cyclopent‐2‐enone Substrate via a Tandem Photochemical Transformation and an Allylic Substitution Protocol;Advanced Synthesis & Catalysis;2023-10-18
2. C(sp2)–H cyclobutylation of hydroxyarenes enabled by silver-π-acid catalysis: diastereocontrolled synthesis of 1,3-difunctionalized cyclobutanes;Chemical Science;2023
3. Investigating Bicyclobutane–Triazolinedione Cycloadditions as a Tool for Peptide Modification;Organic Letters;2022-01-11
4. Diastereoselective Synthesis of TAK-828F;Synfacts;2021-10-19
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