Discovery of Two Clinical Histamine H3 Receptor Antagonists: trans-N-Ethyl-3-fluoro-3-[3-fluoro-4-(pyrrolidinylmethyl)phenyl]cyclobutanecarboxamide (PF-03654746) and trans-3-Fluoro-3-[3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl]-N-(2-methylpropyl)cyclobutanecarboxamide (PF-03654764)-Reference-Cited by-同舟云学术

Discovery of Two Clinical Histamine H3 Receptor Antagonists: trans-N-Ethyl-3-fluoro-3-[3-fluoro-4-(pyrrolidinylmethyl)phenyl]cyclobutanecarboxamide (PF-03654746) and trans-3-Fluoro-3-[3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl]-N-(2-methylpropyl)cyclobutanecarboxamide (PF-03654764)

Published:2011-10-07 Issue:21 Volume:54 Page:7602-7620
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Wager Travis T.¹,Pettersen Betty A.¹,Schmidt Anne W.¹,Spracklin Douglas K.¹,Mente Scot¹,Butler Todd W.¹,Howard Harry¹,Lettiere Daniel J.¹,Rubitski David M.¹,Wong Diane F.¹,Nedza Frank M.¹,Nelson Frederick R.¹,Rollema Hans¹,Raggon Jeffrey W.¹,Aubrecht Jiri¹,Freeman Jody K.¹,Marcek John M.¹,Cianfrogna Julie¹,Cook Karen W.¹,James Larry C.¹,Chatman Linda A.¹,Iredale Philip A.¹,Banker Michael J.¹,Homiski Michael L.¹,Munzner Jennifer B.¹,Chandrasekaran Rama Y.¹

Affiliation:

1. Groton Laboratories, Pfizer Worldwide Research and Development, 558 Eastern Point Road, Groton, Connecticut 06340-5159, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm200939b

Reference52 articles.

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2. Definition and Antagonism of Histamine H2-receptors

3. Keynote review: Histamine H3 receptor antagonists reach out for the clinic