Recent developments in the synthesis of azaindoles from pyridine and pyrrole building blocks-Reference-Cited by-同舟云学术

Recent developments in the synthesis of azaindoles from pyridine and pyrrole building blocks

Published:2021 Issue:3 Volume:8 Page:466-513
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Motati Damoder Reddy¹²³⁴^ORCID,Amaradhi Radhika¹²³⁴^ORCID,Ganesh Thota¹²³⁴^ORCID

Affiliation:

1. Department of Pharmacology and Chemical Biology

2. Emory School of Medicine

3. Atlanta

4. USA

Abstract

The azaindole framework is ubiquitous in bioactive natural products and pharmaceuticals. This review highlights the synthetic approaches to azaindoles with advantages and limitations, mechanistic pathways and biological importance.

Funder

National Institutes of Health

National Institute of Neurological Disorders and Stroke

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/QO/D0QO01079K

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1. Luminescence and reactivity of 7-azaindole derivatives and complexes

2. Discovery and Characterization of AZD6738, a Potent Inhibitor of Ataxia Telangiectasia Mutated and Rad3 Related (ATR) Kinase with Application as an Anticancer Agent

3. Azaindolylsulfonamides, with a More Selective Inhibitory Effect on Histone Deacetylase 6 Activity, Exhibit Antitumor Activity in Colorectal Cancer HCT116 Cells

4. Inhibitors of HIV-1 Attachment: The Discovery and Development of Temsavir and its Prodrug Fostemsavir

5. Azaindoles: Noncovalent DprE1 Inhibitors from Scaffold Morphing Efforts, Kill Mycobacterium tuberculosis and Are Efficacious in Vivo

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