Azaindoles: Noncovalent DprE1 Inhibitors from Scaffold Morphing Efforts, Kill Mycobacterium tuberculosis and Are Efficacious in Vivo-Reference-Cited by-同舟云学术

Azaindoles: Noncovalent DprE1 Inhibitors from Scaffold Morphing Efforts, Kill Mycobacterium tuberculosis and Are Efficacious in Vivo

Published:2013-11-21 Issue:23 Volume:56 Page:9701-9708
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Shirude Pravin S.¹,Shandil Radha²,Sadler Claire³,Naik Maruti¹,Hosagrahara Vinayak²,Hameed Shahul¹,Shinde Vikas¹,Bathula Chandramohan¹,Humnabadkar Vaishali⁴,Kumar Naveen²,Reddy Jitendar²,Panduga Vijender²,Sharma Sreevalli⁴,Ambady Anisha⁴,Hegde Naina⁴,Whiteaker James⁵,McLaughlin Robert E.⁵,Gardner Humphrey⁵,Madhavapeddi Prashanti⁴,Ramachandran Vasanthi⁴,Kaur Parvinder⁴,Narayan Ashwini⁴,Guptha Supreeth⁴,Awasthy Disha⁴,Narayan Chandan⁴,Mahadevaswamy Jyothi⁴,Vishwas KG²,Ahuja Vijaykamal²,Srivastava Abhishek²,Prabhakar KR²,Bharath Sowmya²,Kale Ramesh¹,Ramaiah Manjunatha¹,Choudhury Nilanjana Roy¹,Sambandamurthy Vasan K.⁴,Solapure Suresh²,Iyer Pravin S.¹,Narayanan Shridhar⁴,Chatterji Monalisa⁴

Affiliation:

1. Department of Medicinal Chemistry, IMED Infection, AstraZeneca India, Bellary Road, Hebbal, Bangalore 560024, India

2. DMPK and Animal Sciences, IMED Infection, AstraZeneca, Bangalore 560024, India

3. Safety Assessment, IMED Infection, AstraZeneca, Alderly Park, Mereside, U.K.

4. Department of Biosciences, IMED Infection, AstraZeneca, Bangalore 560024, India

5. Translational Science, IMED Infection, AstraZeneca, Waltham, Massachusetts, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm401382v

Reference13 articles.

1. Scaling up interventions to achieve global tuberculosis control: progress and new developments

2. Global Tuberculosis Report;World Health Organization:Geneva, 2012.

3. Approval of Novel TB Drug Celebrated—With Restraint

4. Benzothiazinones: Prodrugs That Covalently Modify the Decaprenylphosphoryl-β-d-ribose 2′-epimerase DprE1 of Mycobacterium tuberculosis

5. Decaprenylphosphoryl Arabinofuranose, the Donor of the d -Arabinofuranosyl Residues of Mycobacterial Arabinan, Is Formed via a Two-Step Epimerization of Decaprenylphosphoryl Ribose

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