Preparation of spiro[indole-3,5′-isoxazoles] via Grignard conjugate addition/spirocyclization sequence
Author:
Affiliation:
1. Department of Chemistry
2. North Caucasus Federal University
3. Stavropol 355009
4. Russian Federation
Abstract
One-pot procedure combining conjugate addition of Grignard reagents to (2-nitroalkenyl)indoles and subsequent acid-assisted spirocyclization allowed for diastereoselective preparation of 4′H-spiro[indole-3,5′-isoxazoles].
Funder
Russian Science Foundation
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemical Engineering,General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2021/RA/D0RA10219A
Reference27 articles.
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2. Efficient assembly of 3-substituted oxindole-based isoxazolines leading to the synthesis of (±)-flustraminol-B and related natural product building blocks
3. Copper-Catalyzed [3+2] Cycloaddition and Interrupted Fischer Indolization to Prepare Polycyclic Furo[2,3-b]indolines from N -Aryl Isatin Nitrones and Methylenecyclopropanes
4. Synthesis and evaluation of spiroisoxazoline oxindoles as anticancer agents
5. Synthesis and Antimicrobial and Antifungal Activity of Carbamate-Functionized Spiro Compounds
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