Direct Conversion of 3-(2-Nitroethyl)-1H-Indoles into 2-(1H-Indol-2-yl)Acetonitriles-Reference-Cited by-同舟云学术

Direct Conversion of 3-(2-Nitroethyl)-1H-Indoles into 2-(1H-Indol-2-yl)Acetonitriles

Published:2021-10-11 Issue:20 Volume:26 Page:6132
ISSN:1420-3049
Container-title:Molecules
language:en
Short-container-title:Molecules

Author:

Aksenov Alexander V.^ORCID,Aksenov Nicolai A.^ORCID,Aleksandrova Elena V.,Aksenov Dmitrii A.^ORCID,Grishin Igor Yu.^ORCID,Sorokina Elena A.^ORCID,Wenger Allison,Rubin Michael^ORCID

Abstract

The recently discovered [4+1]-spirocyclization of nitroalkenes to indoles provided a convenient new approach to 2-(1H-indol-2-yl)acetonitriles. However, this reaction was complicated by the formation of inert 3-(2-nitroethyl)-1H-indole byproducts. Herein, we offer a workaround this problem that allows for effective transformation of the unwanted byproducts into acetonitrile target molecules.

Funder

Russian Science Foundation

Publisher

MDPI AG

Subject

Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science

Link

https://www.mdpi.com/1420-3049/26/20/6132/pdf

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