Reconstructive Methodology in the Synthesis of 2-Aminopurine-Reference-Cited by-同舟云学术

Reconstructive Methodology in the Synthesis of 2-Aminopurine

Published:2023-12-25 Issue:1 Volume:29 Page:134
ISSN:1420-3049
Container-title:Molecules
language:en
Short-container-title:Molecules

Author:

Neymash Artyom O.¹,Ulomsky Evgeny N.¹,Fedotov Victor V.¹,Aminov Semen V.¹,Lyapustin Daniil N.¹^ORCID,Gorbunov Evgeny B.²,Ishimnikov Vladislav A.¹,Slepukhin Pavel A.²,Rusinov Vladimir L.¹

Affiliation:

1. Chemical Engineering Institute, Ural Federal University, 19 Mira St., 620002 Yekaterinburg, Russia

2. Institute of Organic Synthesis, Ural Branch of the Russian Academy of Science, Sofii Kovalevskoy St. 22, 620137 Yekaterinburg, Russia

Abstract

A fundamentally new synthetic approach to the synthesis of 2-aminopurine has been developed. It consists in the combination of the creation of a condensed polyazotic heterocyclic tetrazolopyrimidine structure, its transformation into triaminopyrimidine, and its subsequent cyclization into 2-aminopurine. The structure of the obtained compounds was established based on spectral characteristics, and the structure of the intermediate compound 5 was established directly by X-ray diffraction analysis.

Funder

Russian Science Foundation

Publisher

MDPI AG

Subject

Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science

Link

https://www.mdpi.com/1420-3049/29/1/134/pdf

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