The uncommon strong inhibition of α-glucosidase by multivalent glycoclusters based on cyclodextrin scaffolds-Reference-Cited by-同舟云学术

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The uncommon strong inhibition of α-glucosidase by multivalent glycoclusters based on cyclodextrin scaffolds

Published:2019 Issue:30 Volume:17 Page:7228-7237
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Alali Urjwan¹²³⁴⁵,Vallin Aurélie¹²³⁴⁵,Bil Abed¹²³⁴⁵,Khanchouche Takwa¹²³⁴⁵,Mathiron David⁶⁴⁵⁷^ORCID,Przybylski Cédric⁸⁹¹⁰¹¹⁷^ORCID,Beaulieu Rémi¹²³⁴⁵,Kovensky José¹²³⁴⁵,Benazza Mohammed¹²³⁴⁵,Bonnet Véronique¹²³⁴⁵^ORCID

Affiliation:

1. Laboratoire de Glycochimie

2. des Antimicrobiens et des Agroressources

3. LG2A UMR CNRS 7378

4. Université de Picardie Jules Verne

5. 80039 Amiens

6. Plateforme Analytique

7. France

8. Institut Parisien de Chimie Moléculaire

9. CNRS UMR 8232

10. Sorbonne Université

11. 75252 Paris

Abstract

New inhibitors of α-glucosidase based on perglycosylated cyclodextrins were synthesized via click-chemistry and compared to acarbose.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/OB/C9OB01344J

Reference43 articles.

1. https://www.who.int/news-room/fact-sheets/detail/diabetes (May 2019)

2. Inhibition of α-glucosidase, α-amylase, and aldose reductase by potato polyphenolic compounds

3. Diosgenin from Dioscorea bulbifera: Novel Hit for Treatment of Type II Diabetes Mellitus with Inhibitory Activity against α-Amylase and α-Glucosidase

4. Inhibition of Human and Rat Sucrase and Maltase Activities To Assess Antiglycemic Potential: Optimization of the Assay Using Acarbose and Polyphenols

5. Unprecedented inhibition of glycosidase-catalyzed substrate hydrolysis by nanodiamond-grafted O-glycosides

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1. Amphiphilic α-Peptoid-deoxynojirimycin Conjugate-based Multivalent Glycosidase Inhibitor for Hypoglycemic Effect and Fluorescence Imaging;Journal of Medicinal Chemistry;2024-03-20

2. New Selective Inhibitors of α‐Glucosidase for the Treatment of Type 2 Diabetes Mellitus;Helvetica Chimica Acta;2024-02-29

3. Synthesis and Preliminary Evaluation of an ASGPr-Targeted Polycationic β-Cyclodextrin Carrier for Nucleosides and Nucleotides;Pharmaceutics;2024-02-26

4. Multivalent inhibition of the Aspergillus fumigatus KDNase;Organic & Biomolecular Chemistry;2024

5. Synthetic α-glucosidase inhibitors as promising anti-diabetic agents: Recent developments and future challenges;European Journal of Medicinal Chemistry;2023-03

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