Modelling DNA extension and fragmentation in contractive microfluidic devices: a Brownian dynamics and computational fluid dynamics approach
Author:
Affiliation:
1. Center for Nano and Micro Mechanics
2. School of Aerospace Engineering
3. Tsinghua University
4. Beijing
5. China
Abstract
We simulated the thorough process of DNA fragmentation in microfluidics. The conformation of DNA preconditioned by shear flow and the strain rate of elongational flow are two critical parameters for DNA fragmentation.
Funder
National Natural Science Foundation of China
Publisher
Royal Society of Chemistry (RSC)
Subject
Condensed Matter Physics,General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2018/SM/C8SM00863A
Reference73 articles.
1. Hydrodynamic shearing of DNA in a polymeric microfluidic device
2. Library construction for next-generation sequencing: Overviews and challenges
3. Enhanced Signals and Fast Nucleic Acid Hybridization By Microfluidic Chaotic Mixing
4. Ultra fast miniaturized real-time PCR: 40 cycles in less than six minutes
5. Shotgun DNA sequencing using cloned DNase I-generated fragments
Cited by 11 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Addition of konjac glucomannan improves spraying efficiency on fruits and vegetables: Effect of surface hydrophilicity and molecular weight;International Journal of Biological Macromolecules;2024-02
2. Hydrodynamic tearing of bacteria on nanotips for sustainable water disinfection;Nature Communications;2023-09-15
3. Effects of Microfluidic Shear on the Plasmid DNA Structure: Implications for Polymeric Gene Delivery Vectors;Langmuir;2023-08-08
4. Adding Konjac Glucomannan for Enhancing the Whole Spraying Performance on Superhydrophobic and Hydrophilic Surfaces;ACS Applied Materials & Interfaces;2023-05-15
5. Efficient and accurate multi-scale simulation for viscosity mechanism of konjac glucomannan colloids;International Journal of Biological Macromolecules;2023-05
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3