Human neuromuscular junction on micro-structured microfluidic devices implemented with a custom micro electrode array (MEA)-Reference-Cited by-同舟云学术

Human neuromuscular junction on micro-structured microfluidic devices implemented with a custom micro electrode array (MEA)

Published:2021 Issue:21 Volume:21 Page:4223-4236
ISSN:1473-0197
Container-title:Lab on a Chip
language:en
Short-container-title:Lab Chip

Author:

Duc Pauline¹^ORCID,Vignes Michel²,Hugon Gérald³,Sebban Audrey⁴,Carnac Gilles³^ORCID,Malyshev Eugene⁴,Charlot Benoît⁴^ORCID,Rage Florence¹^ORCID

Affiliation:

1. IGMM, University of Montpellier, CNRS, Montpellier, France

2. IBMM UMR5247, University of Montpellier, CNRS, Montpellier, France

3. PhyMedExp, INSERM U1046, CNRS UMR9214, Université de Montpellier, Montpellier, France

4. IES, CNRS University of Montpellier, Montpellier 34095, France

Abstract

Microfluidic devices were coupled with custom MEA and used for co-culture of human motor neurons and muscles. This allowed to assess human NMJ activity by electrical stimulation of axons and recording of subsequent muscle action potentials.

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2021/LC/D1LC00497B

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