Development of curcumin-loaded zein nanoparticles for transport across the blood–brain barrier and inhibition of glioblastoma cell growth-Reference-Cited by-同舟云学术

Development of curcumin-loaded zein nanoparticles for transport across the blood–brain barrier and inhibition of glioblastoma cell growth

Published:2021 Issue:21 Volume:9 Page:7092-7103
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Zhang Huaiying¹,van Os Winant L.²,Tian Xiaobo³,Zu Guangyue¹,Ribovski Laís¹^ORCID,Bron Reinier¹,Bussmann Jeroen⁴,Kros Alexander²^ORCID,Liu Yong¹,Zuhorn Inge S.¹^ORCID

Affiliation:

1. Department of Biomedical Engineering, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

2. Department of Supramolecular and Biomaterials Chemistry, Leiden Institute of Chemistry, Leiden University, Leiden, The Netherlands

3. Department of Analytical Biochemistry and Interfaculty Mass Spectrometry Center, Groningen Research Institute of Pharmacy, University of Groningen, Groningen, The Netherlands

4. Division of BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands

Abstract

Zein-polydopamine nanoparticles functionalized with G23 peptide cross an in vitro blood–brain barrier and penetrate tumor spheroids. When loaded with curcumin they effectively reduce proliferation, migration, and viability of C6 glioma cells.

Funder

China Scholarship Council

Stichting De Cock-Hadders

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2021/BM/D0BM01536A

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1. A Phase II study of paclitaxel in patients with recurrent malignant glioma using different doses depending upon the concomitant use of anticonvulsants

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