Advancing predictions of protein stability in the solid state-Reference-Cited by-同舟云学术

Advancing predictions of protein stability in the solid state

Published:2020 Issue:30 Volume:22 Page:17247-17254
ISSN:1463-9076
Container-title:Physical Chemistry Chemical Physics
language:en
Short-container-title:Phys. Chem. Chem. Phys.

Author:

Batens Maarten¹²³⁴^ORCID,Shmool Talia A.⁵⁶⁷⁸^ORCID,Massant Jan⁹¹⁰¹¹⁴^ORCID,Zeitler J. Axel⁵⁶⁷⁸^ORCID,Van den Mooter Guy¹²³⁴^ORCID

Affiliation:

1. Drug Delivery and Disposition

2. KU Leuven

3. Leuven

4. Belgium

5. Department of Chemical Engineering and Biotechnology

6. University of Cambridge

7. Cambridge

8. UK

9. Biological Formulation Development

10. UCB Pharma

11. Braine l'Alleud

Abstract

Investigating the different relaxation dynamics of glassy solid state monoclonal antibody formulations and how these relate to protein stability within the framework of the energy landscape.

Funder

AstraZeneca

Engineering and Physical Sciences Research Council

UCB

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Link

http://pubs.rsc.org/en/content/articlepdf/2020/CP/D0CP00341G

Reference31 articles.

1. Characteristics and Significance of the Amorphous State in Pharmaceutical Systems

2. Correlations between Molecular Mobility and Chemical Stability During Storage of Amorphous Pharmaceuticals

3. Stabilization of proteins in solid form

4. Coupling between lysozyme and trehalose dynamics: Microscopic insights from molecular-dynamics simulations

5. β-Relaxation governs protein stability in sugar-glass matrices

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