Highly enantioselective Rh-catalyzed asymmetric reductive dearomatization of multi-nitrogen polycyclic pyrazolo[1,5-<i>a</i>]pyrimidines-Reference-Cited by-同舟云学术

Highly enantioselective Rh-catalyzed asymmetric reductive dearomatization of multi-nitrogen polycyclic pyrazolo[1,5-a]pyrimidines

Published:2023 Issue:34 Volume:14 Page:9048-9054
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Xie Chaochao¹,Xiao Guiying¹,Guo Qianling¹,Wu Xiaoxue¹,Zi Guofu¹^ORCID,Ding Wanjian¹,Hou Guohua¹²^ORCID

Affiliation:

1. Key Laboratory of Radiopharmaceuticals, College of Chemistry, Beijing Normal University, No. 19 Xinjiekouwai St., Beijing 100875, China

2. Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China

Abstract

A highly enantioselective Rh-catalyzed reductive dearomatization of pyrazolo[1,5-a]pyrimidines has been realized for the first time by two strategies to afford chiral 4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidines with excellent enantioselectivities, up to 98% ee.

Funder

National Natural Science Foundation of China

Beijing Municipal Natural Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/SC/D3SC02086J

Reference40 articles.

1. Targeting the Binding Function 3 (BF3) Site of the Human Androgen Receptor through Virtual Screening.

2. GdCl3 promoted synthesis of novel pyrimidine fused indazole derivatives and their anticancer activity