Iridium-Catalyzed Asymmetric Hydrogenation of Heteroaromatics with Multiple N Atoms via Substrate Activation: An Entry to 4,5,6,7-Tetrahydropyrazolo[1,5-<i>a</i>]pyrimidine-3-carbonitrile Core of a Potent BTK Inhibitor-Reference-Cited by-同舟云学术

Iridium-Catalyzed Asymmetric Hydrogenation of Heteroaromatics with Multiple N Atoms via Substrate Activation: An Entry to 4,5,6,7-Tetrahydropyrazolo[1,5-a]pyrimidine-3-carbonitrile Core of a Potent BTK Inhibitor

Published:2024-03-11 Issue:7 Volume:89 Page:4336-4348
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Chen Mu-Wang¹^ORCID,Li Hong-Wang¹,Wang Ying-Qi¹,Wu Bo¹^ORCID,Liu Zheng¹,Lai Xinzhong²,Deerberg Joerg²,Zhou Yong-Gui¹^ORCID

Affiliation:

1. State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, Liaoning 116023, P. R. China

2. Chemical Process Research and Development, Department of Chemistry, BeiGene, Ltd., No. 30 Science Park Rd, Zhong-Guan-Cun Life Science Park, Changping District, Beijing 102206, P. R. China

Funder

K. C. Wong Education Foundation

National Natural Science Foundation of China

Bureau of Science and Technology of Liaoning Province

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.joc.3c02396

Reference49 articles.

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5. Discovery of Zanubrutinib (BGB-3111), a Novel, Potent, and Selective Covalent Inhibitor of Bruton’s Tyrosine Kinase

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